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Chronic complement-mediated hemolysis is the underlying cause of progressive morbidities and mortality in PNH1

PNH symptom incidence rate

Patient Screening Diagram

Early intervention is critical

  • 35% of PNH patients die within 5 years of diagnosis2
  • Diagnosis typically delayed for up to 10 years3
  • A full clinical assessment consisting of patient history, physical and laboratory values is crucial for diagnosis and ongoing monitoring of PNH
  • Reported symptoms may vary between visits and patients
    • It is important to discuss symptomatology at each visit to track disease progression

*At initial diagnosis

References

Connect with your local PNH Expert for any questions regarding the diagnosis, treatment or management of PNH. We are here to help.

References

*At initial diagnosis

  1. Brodsky RA. Advances in the diagnosis and therapy of PNH. Blood Rev. 2008;22:65-74.
  2. Hillmen P, Lewis SM, Bessler M, et al. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995;333:1253-1258.
  3. Dacie JV, Lewis SM. PNH: clinical manifestations, haematology, and nature of the disease. Ser Haematol. 1972;5:3-23.
  4. Meyers G, Weitz I, Lamy T, et al. Disease-related symptoms reported across a broad population of patients with PNH. Blood (ASH Annual Meeting Abstracts). 2007;110: Abstract 3683.
  5. Hill A, Rother RP, Wang X, et al. Br J Haematol. 2010;149:414-425.
  6. Hillmen P, Elebute M, Kelly R, et al. Am J Hematol. 2010;85:553-559.
  7. Rosse WF. Paroxysmal nocturnal hemoglobinuria. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone; 2000:331-342.
  8. Nishimura J-I, Kanakura Y, Ware RE, et al. Clinical course and flow cytometric analysis of PNH in the United States and Japan. Medicine. 2004;83:193-207.